We investigated the impact of dispersible zinc tablets on postoperative sore throat (POST) experienced by patients after endotracheal intubation. In our study, 88 patients were divided into two groups. One group received a 40 mg zinc tablet, while the other received a placebo 30 minutes before their surgery.
Our findings revealed that the zinc group reported significantly fewer instances of POST at the 4-hour mark compared to the placebo group. Specifically, only 6.8% of patients in the zinc group experienced POST, while a higher 31.8% in the placebo group did. Furthermore, none of the patients taking zinc reported severe sore throat, a stark contrast to three patients in the placebo group who did.
Additionally, we noted lower severity ratings for sore throat in the zinc group at various time intervals post-surgery. The results emphasize that taking zinc tablets before surgery can effectively mitigate the incidence and discomfort of sore throat following intubation, presenting a simple solution for a common postoperative issue.
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9
Zinc reduces postoperative sore throat
The Effect of Zinc Lozenge on Postoperative Sore Throat: A Prospective Randomized, Double-Blinded, Placebo-Controlled Study.
We explored the potential benefits of zinc lozenges for easing postoperative sore throat (POST), a common discomfort following endotracheal intubation. By conducting a randomized, double-blinded trial with 79 patients undergoing low- to moderate-risk surgeries, we divided participants into two groups: one received zinc lozenges, while the other was given a placebo.
Our findings revealed promising results. At the crucial four-hour mark post-surgery, only 7% of patients who took zinc experienced POST, compared to 29% in the placebo group. Interestingly, the difference was even more pronounced right after surgery, where the zinc group reported a 0% incidence of POST versus 24% for the control group.
Moreover, the severity of sore throat symptoms was notably less intense among those in the zinc group. Those with mild and moderate sore throat pains reported significantly lower severity scores. These results suggest that a single dose of 40 mg of zinc lozenges taken just 30 minutes before surgery can greatly aid in reducing both the occurrence and discomfort of POST in the early hours after surgery.
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9.5
Zinc reduces postoperative sore throat
A randomised, double-blind, comparative study of preoperative magnesium sulphate versus zinc sulphate gargle for prevention of postoperative sore throat following endotracheal intubation.
We conducted a study to understand how well zinc can help prevent postoperative sore throat (POST) after endotracheal intubation. We compared the effects of gargling with zinc sulphate versus magnesium sulphate in a controlled trial involving 132 patients. Those in the zinc group received a solution with 40 mg of elemental zinc, while the magnesium group used 20 mg/kg of magnesium sulphate, with a control group receiving only dextrose.
Our findings showed that the group using zinc sulphate experienced notably lower rates of sore throat compared to those using magnesium sulphate. Specifically, the incidence of mild POST was significantly lower in the zinc group, especially during the first four hours after surgery. Overall, zinc gargle proved to be more effective in reducing sore throat compared to magnesium sulphate, demonstrating its potential benefits in postoperative care.
These results highlight the importance of zinc as a simple yet effective intervention to reduce discomfort for patients following surgery. By using zinc gargle preoperatively, we can potentially improve patient outcomes related to postoperative sore throat.
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Most Useful Reviews
9
Very effective product
109 people found this helpful
This product is good for sore throat and has proven to be very effective.
Read More
9
Helpful during illness
6 people found this helpful
Helps a lot during a sore throat, cold, or runny nose.
Read More
9
Pleasant relief
5 people found this helpful
I purchased this for my sore throat caused by a coronavirus infection. It tastes delightful and has a ramune-like shape. It’s small, and even my husband, who typically avoids medicine, enjoyed it. It effectively eased my sore throat.
A randomised, double-blind, comparative study of preoperative magnesium sulphate versus zinc sulphate gargle for prevention of postoperative sore throat following endotracheal intubation.
We conducted a study to understand how well zinc can help prevent postoperative sore throat (POST) after endotracheal intubation. We compared the effects of gargling with zinc sulphate versus magnesium sulphate in a controlled trial involving 132 patients. Those in the zinc group received a solution with 40 mg of elemental zinc, while the magnesium group used 20 mg/kg of magnesium sulphate, with a control group receiving only dextrose.
Our findings showed that the group using zinc sulphate experienced notably lower rates of sore throat compared to those using magnesium sulphate. Specifically, the incidence of mild POST was significantly lower in the zinc group, especially during the first four hours after surgery. Overall, zinc gargle proved to be more effective in reducing sore throat compared to magnesium sulphate, demonstrating its potential benefits in postoperative care.
These results highlight the importance of zinc as a simple yet effective intervention to reduce discomfort for patients following surgery. By using zinc gargle preoperatively, we can potentially improve patient outcomes related to postoperative sore throat.
Read More
9.5
Zinc reduces postoperative sore throat
Preoperative oral zinc tablet decreases incidence of postoperative sore throat.
We investigated the impact of dispersible zinc tablets on postoperative sore throat (POST) experienced by patients after endotracheal intubation. In our study, 88 patients were divided into two groups. One group received a 40 mg zinc tablet, while the other received a placebo 30 minutes before their surgery.
Our findings revealed that the zinc group reported significantly fewer instances of POST at the 4-hour mark compared to the placebo group. Specifically, only 6.8% of patients in the zinc group experienced POST, while a higher 31.8% in the placebo group did. Furthermore, none of the patients taking zinc reported severe sore throat, a stark contrast to three patients in the placebo group who did.
Additionally, we noted lower severity ratings for sore throat in the zinc group at various time intervals post-surgery. The results emphasize that taking zinc tablets before surgery can effectively mitigate the incidence and discomfort of sore throat following intubation, presenting a simple solution for a common postoperative issue.
Read More
9
Zinc reduces postoperative sore throat
The Effect of Zinc Lozenge on Postoperative Sore Throat: A Prospective Randomized, Double-Blinded, Placebo-Controlled Study.
We explored the potential benefits of zinc lozenges for easing postoperative sore throat (POST), a common discomfort following endotracheal intubation. By conducting a randomized, double-blinded trial with 79 patients undergoing low- to moderate-risk surgeries, we divided participants into two groups: one received zinc lozenges, while the other was given a placebo.
Our findings revealed promising results. At the crucial four-hour mark post-surgery, only 7% of patients who took zinc experienced POST, compared to 29% in the placebo group. Interestingly, the difference was even more pronounced right after surgery, where the zinc group reported a 0% incidence of POST versus 24% for the control group.
Moreover, the severity of sore throat symptoms was notably less intense among those in the zinc group. Those with mild and moderate sore throat pains reported significantly lower severity scores. These results suggest that a single dose of 40 mg of zinc lozenges taken just 30 minutes before surgery can greatly aid in reducing both the occurrence and discomfort of POST in the early hours after surgery.
Read More
8
Zinc's role in sore throat treatment
The Effectiveness of a Dietary Supplement with Honey, Propolis, Extract, and Zinc in Children Affected by Acute Tonsillopharyngitis: An Open, Randomized, and Controlled Trial.
We evaluated a promising dietary supplement that combines honey, propolis, and zinc to see how effective it could be for children suffering from acute tonsillopharyngitis, a type of sore throat. In this open-label, randomized, and controlled study, we compared the supplement along with standard care against standard care alone over six days.
The results revealed that incorporating the supplement with standard care led to notable improvements in certain symptoms associated with sore throat, such as throat pain and swallowing difficulties by day four and six. Although zinc was part of the blend, it was challenging to pinpoint its independent effect, given that it was studied alongside honey and propolis.
Interestingly, only one child in the standard care group needed additional medications like ibuprofen, highlighting that the supplement may reduce the need for further treatment. Importantly, we did not report any adverse events, making this combination a potential safe addition to treatment.
Overall, while the study presents encouraging results regarding the adjunctive use of the supplement in treating sore throat, it remains unclear how much zinc alone contributes to its effectiveness.
Read More
8
Zinc's variable effectiveness for sore throat
Zinc deficits, mucositis, and mucosal macrophage perturbation: is there a relationship?
We examined recent findings regarding zinc's impact on sore throat, particularly in post-operative settings. Some studies have reported that specific zinc formulations, like polaprezinc, can effectively reduce symptoms associated with sore throat after procedures like endotracheal intubation.
Importantly, zinc sulfate showed mixed results, with one review suggesting it did not significantly decrease the occurrence or intensity of oral mucositis in cancer patients. However, there are indications that certain zinc preparations may still hold promise in specific contexts, such as managing sore throat post-surgery.
Overall, while zinc's benefits in sore throat treatment appear to vary, ongoing research explores the best applications and formulations of zinc to potentially ease discomfort. As such, individuals seeking relief should keep an eye on emerging studies that could clarify zinc's role in throat health.
This product is good for sore throat and has proven to be very effective.
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9
Helpful during illness
6 people found this helpful
Helps a lot during a sore throat, cold, or runny nose.
Read More
9
Pleasant relief
5 people found this helpful
I purchased this for my sore throat caused by a coronavirus infection. It tastes delightful and has a ramune-like shape. It’s small, and even my husband, who typically avoids medicine, enjoyed it. It effectively eased my sore throat.
Read More
10
Emergency relief
4 people found this helpful
Wonderful! This is my salvation and emergency aid! As soon as I feel my throat starting to hurt, I dissolve one piece, and the next day my throat is usually fine. It's brilliant! I even gave my mother-in-law a jar since she suffers from a chronic sore throat.
Read More
9
Quick relief
4 people found this helpful
These lozenges relieve my sore throat quickly, and I enjoy their taste as well.
A sore throat, also known as pharyngitis, is a common condition characterized by pain, scratchiness, or irritation of the throat. It can occur as a result of various factors, including viral infections like the common cold or flu, bacterial infections such as strep throat, allergies, dry air, or even irritants like smoke and pollution. Symptoms often manifest as a sensation of discomfort during swallowing and may be accompanied by swelling, redness, or the presence of white patches on the tonsils or throat lining.
Most sore throats are mild and resolve on their own within a week or so, often treated with home remedies such as warm salt water gargles, lozenges, and hydration. However, if the sore throat is severe, persistent, or associated with other concerning symptoms such as high fever, difficulty swallowing, or difficulty breathing, it's essential to consult a healthcare professional, as this may indicate a more serious condition that requires medical intervention. Proper diagnosis and treatment are crucial, especially if a bacterial infection is suspected, as it may necessitate antibiotics for effective treatment.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc has been studied for its potential effects on the immune system, and some evidence suggests it may help alleviate sore throat symptoms. Particularly, zinc lozenges or syrups may shorten the duration of a sore throat when taken at the onset of symptoms. The reasoning behind this is that zinc can inhibit the replication of the virus responsible for the cold and boost immune response, thus potentially providing some relief.
However, it’s important to use zinc cautiously, as high doses can lead to side effects such as nausea or a bad taste in the mouth. Most health experts recommend opting for zinc in moderate doses, ideally through lozenges, which can also provide some soothing effects. While zinc might not be a cure-all, it can be a helpful part of a broader treatment plan that includes rest, hydration, and over-the-counter pain relievers. If your sore throat persists or is accompanied by other severe symptoms, consulting with a healthcare professional is advisable.
Based on user reviews, many report that noticeable relief from sore throat symptoms can occur quite quickly after taking these lozenges. Several users indicated that they feel significant improvement within one day of use; for instance, one reviewer mentioned, "As soon as I feel my throat starting to hurt, I dissolve one piece, and the next day my throat is usually fine" Read Review. Another user highlighted similar results, stating they suck on one every few hours and typically find their sore throat resolved within a day (Read Review).
Additionally, some users noted that a course of treatment spanning a few days also leads to complete recovery, with one reviewer reporting relief from the initial symptoms of a cold within 2-3 days (Read Review). Overall, while experiences may vary, it seems that these lozenges can provide rapid relief for many users dealing with sore throats, often within a day or so.
The use of zinc and its formulations shows some promise for treating sore throat symptoms, particularly in specific contexts like acute tonsillopharyngitis in children. A controlled study revealed that a dietary supplement combining honey, propolis, and zinc notably improved symptoms such as throat pain and swallowing difficulties when added to standard care, reducing the need for additional medications [1]. However, while zinc is one of the ingredients, isolating its specific contributions to the overall effectiveness remains challenging, as other ingredients like honey and propolis are also involved [2].
In surgical contexts, zinc proved effective for mitigating postoperative sore throat discomfort, with studies showing that patients taking zinc lozenges or gargles experienced significantly fewer instances and lower severity of sore throat symptoms compared to placebo groups [7][3]. However, evidence concerning its efficacy for sore throats outside of postoperative care is less clear. For instance, some studies indicate that although certain zinc formulations may reduce symptoms in postoperative cases, the benefits in treating common sore throat cases resulting from infections or colds are not as well supported [9]. Therefore, while zinc may be beneficial in certain circumstances, more research is needed to delineate its overall effectiveness in treating sore throat.
Based on user reviews, many individuals have reported significant improvements in sore throat symptoms after using these lozenges. Users describe rapid relief, often stating that the soreness diminishes almost immediately or within a day of use. For example, one reviewer noted, "After sucking on one pill, the pain nearly vanished," highlighting the quick action of the lozenges in providing relief Read Review. Others have shared similar sentiments, with reports indicating that just a few lozenges a day can lead to feeling fine the next day, showcasing their effectiveness against the discomfort associated with sore throats and colds Read Review.
Moreover, some users noted that these lozenges are not only effective for immediate relief but also play a role in their overall wellness during illness. One user mentioned an improvement in general well-being after just a couple of doses, and another highlighted their preventive benefits when taken at the onset of symptoms Read Review. While individual experiences can vary, the consensus appears to be that these lozenges are a reliable solution for many looking to alleviate sore throat discomfort quickly.
Based on user reviews, many individuals reported positive experiences when combining these lozenges with other supplements for managing sore throat symptoms. One user specifically mentioned that while these lozenges are effective for sore throat relief, they also found that taking zinc capsules is preferable for illness prevention, suggesting a complementary approach during cold symptoms Read Review. Another reviewer remarked that they consumed multiple tablets daily which seemed to resolve their throat issues effectively within three days, implying that this supplement can be taken alongside other treatments for enhanced results Read Review.
Users also noted the importance of timing with their supplement intake. For instance, some found that taking the lozenges after meals helped prevent nausea, allowing them to continue with their other wellness routines without discomfort Read Review. Furthermore, families reported that everyone could benefit from the lozenges, indicating a broad appeal that complements other vitamin or mineral supplements typically taken during cold season Read Review. Overall, users highlighted that these lozenges can effectively work in conjunction with other supplements to better manage sore throat and cold symptoms.
Users have shared positive experiences regarding the effective use of zinc lozenges for treating sore throats, although there is a variety in reported dosages. Some reviewers suggest that taking one lozenge can provide immediate relief, often stating that the discomfort can dissipate relatively quickly thereafter. For instance, one user noted that sucking on a lozenge at the first sign of throat pain resulted in significant relief by the next day Read Review. Another user mentioned that consuming around 6 tablets daily for three days was effective in resolving their sore throat symptoms Read Review.
Users also recommend taking these lozenges after meals to mitigate any potential stomach discomfort often associated with zinc tablets Read Review. Overall, while the consensus suggests that using zinc lozenges can alleviate sore throat symptoms effectively, the specific dosing experience seems to vary, with some finding success at lower dosages and others opting for more frequent intake.
10
Emergency relief
4 people found this helpful
Wonderful! This is my salvation and emergency aid! As soon as I feel my throat starting to hurt, I dissolve one piece, and the next day my throat is usually fine. It's brilliant! I even gave my mother-in-law a jar since she suffers from a chronic sore throat.
9
Effective against colds
1 people found this helpful
This zinc is excellent, especially if you have a cold or a bit of a sore throat. I simply suck on one every few hours, and it's usually gone within a day, at least in my experience.
9
Effective for colds
1 people found this helpful
These tablets are excellent for the initial symptoms of a cold. They relieve my sore throat and enhance my overall well-being. After a couple of pills, I feel fantastic, and within 2-3 days, my cold is resolved. I give half to my child, who enjoys them. Just be sure not to take them on an empty stomach.
9
Pain relief quickly
1 people found this helpful
Recently, I had a sore throat and after sucking on one pill, the pain nearly vanished. It works effectively.
10
Fast sore throat remedy
A great remedy for sore throat. They work wonderfully when my throat starts to feel sore. A few pills a day, and the next day I feel fine. Resorbing them causes no issues.
8
Proactive sore throat care
3 people found this helpful
Relieves sore throat and redness if you're already feeling discomfort. To prevent illness, zinc capsules are preferable. However, if you are ill, this form works better. I like that it needs to be dissolved without eating for effectiveness. My throat is weak and problematic, but it helps me. If my review is helpful, please like it. Wishing health to you and your family!
10
Quick recovery
Helped well for sore throat! I consumed 6 tablets daily and everything resolved in 3 days! I highly recommend it.
10
Prevented sore throat
2 people found this helpful
I liked these lozenges. They dissolve well when my throat starts to itch, and everything goes away. This winter, I never had a sore throat, and I believe it's thanks to these zinc lozenges. Not everyone likes the taste; my child didn’t appreciate it. I recommend taking them after a meal, as they can make me feel nauseous on an empty stomach.
9
Family favourite
Lozenges with zinc are my go-to remedy for a sore throat and the initial signs of SARS. Our whole family takes them. I highly recommend purchasing these! Wishing good health to everyone in these trying times!
9
Instant relief
1 people found this helpful
Excellent! It truly works! When my throat began to hurt, I sucked one lollipop and voila, by tomorrow I felt great! The children adore the flavour, so I give them to them too. Admittedly, I don't really taste it when it dissolves for long, but it's far better than suffering with a sore throat. I've ordered it for winter.
8
Zinc's role in sore throat treatment
The Effectiveness of a Dietary Supplement with Honey, Propolis, Extract, and Zinc in Children Affected by Acute Tonsillopharyngitis: An Open, Randomized, and Controlled Trial.
We evaluated a promising dietary supplement that combines honey, propolis, and zinc to see how effective it could be for children suffering from acute tonsillopharyngitis, a type of sore throat. In this open-label, randomized, and controlled study, we compared the supplement along with standard care against standard care alone over six days.
The results revealed that incorporating the supplement with standard care led to notable improvements in certain symptoms associated with sore throat, such as throat pain and swallowing difficulties by day four and six. Although zinc was part of the blend, it was challenging to pinpoint its independent effect, given that it was studied alongside honey and propolis.
Interestingly, only one child in the standard care group needed additional medications like ibuprofen, highlighting that the supplement may reduce the need for further treatment. Importantly, we did not report any adverse events, making this combination a potential safe addition to treatment.
Overall, while the study presents encouraging results regarding the adjunctive use of the supplement in treating sore throat, it remains unclear how much zinc alone contributes to its effectiveness.
7
Zinc's role in sore throat relief
The Effects of a Dietary Supplement (PediaFlù) Plus Standard of Care in Children With Acute Tonsillopharyngitis/Rhinopharyngitis: Protocol for a Randomized Controlled Trial.
We targeted the effectiveness of a dietary supplement that includes zinc, among other ingredients, in treating acute tonsillopharyngitis and rhinopharyngitis in children. This trial was carefully designed to compare the supplement combined with standard care against standard care alone.
Our focus was on children aged 3 to 10 years suffering from sore throat symptoms. We employed a randomized, controlled setup, ensuring a solid methodological foundation for our findings. The primary goals included assessing severity of throat pain and the necessity for additional rescue medications.
The results highlighted the supplement's potential as an add-on treatment. While it shows promise in alleviating symptoms, we must note that we cannot isolate zinc's effects from other components like Pelargonium sidoides and propolis.
Ultimately, these insights could guide future treatments where antibiotics are avoided, especially when there's no streptococcal infection involved.
9
Zinc reduces postoperative sore throat
The Effect of Zinc Lozenge on Postoperative Sore Throat: A Prospective Randomized, Double-Blinded, Placebo-Controlled Study.
We explored the potential benefits of zinc lozenges for easing postoperative sore throat (POST), a common discomfort following endotracheal intubation. By conducting a randomized, double-blinded trial with 79 patients undergoing low- to moderate-risk surgeries, we divided participants into two groups: one received zinc lozenges, while the other was given a placebo.
Our findings revealed promising results. At the crucial four-hour mark post-surgery, only 7% of patients who took zinc experienced POST, compared to 29% in the placebo group. Interestingly, the difference was even more pronounced right after surgery, where the zinc group reported a 0% incidence of POST versus 24% for the control group.
Moreover, the severity of sore throat symptoms was notably less intense among those in the zinc group. Those with mild and moderate sore throat pains reported significantly lower severity scores. These results suggest that a single dose of 40 mg of zinc lozenges taken just 30 minutes before surgery can greatly aid in reducing both the occurrence and discomfort of POST in the early hours after surgery.
4
Zinc's limited impact on POST
Role of preoperative zinc, magnesium and budesonide gargles in Postoperative Sore Throat (POST) - a randomised control trial.
We conducted a thorough investigation into the impact of zinc gargles on postoperative sore throat, commonly known as POST. In our recent randomized control trial, we focused on patients undergoing elective surgeries requiring general anesthesia and found a sizable number experiencing POST.
We compared various treatments, including zinc, magnesium, and budesonide, to see which might lessen the soreness after surgery. Our findings revealed that the effects of zinc were similar to those of the other treatments. Unfortunately, we observed no significant advantage in using zinc to reduce sore throat incidence or severity.
Additionally, we noted that surgeries lasting longer than two hours tended to increase the likelihood of POST, regardless of the treatment used. This indicates that the duration of the surgery is an important factor to consider when evaluating sore throat outcomes, rather than solely the preoperative treatments administered.
7
Zinc's effects on sore throat
Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. A randomized, double-blind, placebo-controlled trial.
We conducted a rigorous study to see how zinc acetate lozenges might help reduce the painful and annoying symptoms of the common cold, particularly sore throats. In a well-structured environment, we recruited 50 volunteers who started experiencing cold symptoms within the last 24 hours. Participants were randomly assigned to receive either zinc lozenges or a placebo, taking one every few hours during the day.
Over the course of the study, we monitored various symptoms, including sore throat, and measured participants' plasma zinc and cytokine levels on the first day and as they recovered. We observed that those who took zinc lozenges experienced a shorter duration of cold symptoms, with cough showing notable improvement.
However, when it came to sore throats specifically, while there were positive results, the changes didn't stand out as significantly different from those who received the placebo. So, while zinc may play a role in easing cold symptoms overall, its particular impact on sore throat isn’t conclusively proven in our findings.
References
Cardinale F, Barattini DF, Martinucci V, Bordea MM, Barattini L, et al. The Effectiveness of a Dietary Supplement with Honey, Propolis, Extract, and Zinc in Children Affected by Acute Tonsillopharyngitis: An Open, Randomized, and Controlled Trial. Pharmaceuticals (Basel). 2024;17. doi:10.3390/ph17060804
Cardinale F, Barattini DF, Sbrocca F, Centi A, Giuntini G, et al. The Effects of a Dietary Supplement (PediaFlù) Plus Standard of Care in Children With Acute Tonsillopharyngitis/Rhinopharyngitis: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2024;13:e53703. doi:10.2196/53703
Bhanwra A, Palta S, Saroa R, Saxena P, Bhanwra S, et al. Role of preoperative zinc, magnesium and budesonide gargles in Postoperative Sore Throat (POST) - a randomised control trial. BMC Anesthesiol. 2024;24:164. doi:10.1186/s12871-024-02534-5
Mondal AK, Maiti AK, Chattopadhyay S, Bhar D. A randomised, double-blind, comparative study of preoperative magnesium sulphate versus zinc sulphate gargle for prevention of postoperative sore throat following endotracheal intubation. Indian J Anaesth. 2023;67:S261. doi:10.4103/ija.ija_975_22
Sarkar T, Mandal T. Preoperative oral zinc tablet decreases incidence of postoperative sore throat. Indian J Anaesth. 2020;64:409. doi:10.4103/ija.IJA_959_19
Thomsen M, Vitetta L. Zinc deficits, mucositis, and mucosal macrophage perturbation: is there a relationship?. Curr Opin Clin Nutr Metab Care. 2019;22:365. doi:10.1097/MCO.0000000000000588
Farhang B, Grondin L. The Effect of Zinc Lozenge on Postoperative Sore Throat: A Prospective Randomized, Double-Blinded, Placebo-Controlled Study. Anesth Analg. 2018;126:78. doi:10.1213/ANE.0000000000002494
Sun GB, Sun N, Tang HH, Zhu QB, Wen W, et al. Zinc sulfate therapy of vocal process granuloma. Eur Arch Otorhinolaryngol. 2012;269:2087. doi:10.1007/s00405-012-1971-1
Prasad AS, Fitzgerald JT, Bao B, Beck FW, Chandrasekar PH. Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2000;133:245.